Cell line and Upstream development 

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    Cell line development

      Production of cell and virus stocks

      Cell culture optimization

      Evaluation of Media and cell culture conditions

      Analysis of Multiplicities of Infection

      Determination of cell viability and/or infectious particles

      Various harvest and/or cell disruption methods:

        sonication                  

        micro fluidization

        chemical lysis

     Pilot production and cell culture scale-up

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Downstream

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    Protein purification development

     Chromatography methods to maximize yield and minimize contaminants:

     Size Exclusion

     Anion and Cation Exchange

     Hydrophobic Interaction

     Affinity Protein A chromatography 

     Immunoaffinity chromatography methods

      Filtration:  

     Micro/ultra filtration

     diafiltration

     depth

     CFF

      TFF

        Precipitation methods

        Centrifugation and gradient centrifugation

        Formulations experience 

        Process validation

        Available equipment includes:

    ÄKTA Pilots

   ÄKTA Avant 

   ÄKTA Explorer